End-to-End Continuous Flow Synthesis and Purification of Diphenhydramine Hydrochloride Featuring Atom Economy, In-Line Separation, and Flow of Molten Ammonium Salts
نویسندگان
چکیده
A continuous end-to-end synthesis and purification of diphenhydramine hydrochloride featuring atom economy and waste minimization is described. Combining a 1:1 molar ratio of the two starting material streams (chlorodiphenylmethane and N,N-dimethylaminoethanol) in the absence of additional solvent at high temperature gives the target compound directly as a molten salt (ionic liquid above 168 °C) in high 10
منابع مشابه
Numerical and Experimental Analysis of the Effect of Flow Discharge Ratio on Flow Separation at 45 Degree Open End Water Intake
Flow separation at water intake is the main cause of head loss and flow discharge reduction. 
As a result, study of shape and size of separation is very essential when designing an optimum water intake. Water intake is normally built with a 90 degree angle to the main channel flow direction. However, the flow structure in this type of water intake consists of large separation size along wit...
متن کاملNumerical and Experimental Analysis of the Effect of Flow Discharge Ratio on Flow Separation at 45 Degree Open End Water Intake
Flow separation at water intake is the main cause of head loss and flow discharge reduction. As a result, study of shape and size of separation is very essential when designing an optimum water intake. Water intake is normally built with a 90 degree angle to the main channel flow direction. However, the flow structure in this type of water intake consists of large separation size along with ...
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